Certain antifungal drugs like ketoconazole and itraconazole, as well as antibiotics like erythromycin, can affect how the body metabolizes Tadalafil. These drugs inhibit enzymes in the liver that break down Vidalista 80 , increasing its levels in the blood and raising the risk of side effects. Medications used to manage HIV, such as ritonavir and saquinavir, can also interact with Vidalista 80. These drugs slow down the metabolism of Tadalafil, leading to prolonged exposure to the medication and a higher likelihood of adverse effects.